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Target
Synaptic vesicular amine transporter
Ligand
BDBM50534746
Substrate
n/a
Meas. Tech.
ChEMBL_1929290 (CHEMBL4432466)
Ki
48±n/a nM
Citation
 Nickell, JR; Culver, JP; Janganati, V; Zheng, G; Dwoskin, LP; Crooks, PA Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett 26:4441-4445 (2016) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:
Protein
Mol. Mass.:
55689.58
Organism:
Rattus norvegicus (Rat)
Description:
Q01827
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50534746
Synonyms:
CHEMBL4442303
Type:
Small organic molecule
Emp. Form.:
C20H26Cl4N2
Mol. Mass.:
436.246
SMILES:
Cl.Cl.Clc1ccccc1CCN1CCN(CCc2ccccc2Cl)CC1
Structure:
Search PDB for entries with ligand similarity: