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Target
Histamine H2 receptor
Ligand
BDBM50543283
Substrate
n/a
Meas. Tech.
ChEMBL_1988825 (CHEMBL4622372)
Ki
21±n/a nM
Citation
 Biselli, S; Alencastre, I; Tropmann, K; Erdmann, D; Chen, M; Littmann, T; Maia, AF; Gomez-Lazaro, M; Tanaka, M; Ozawa, T; Keller, M; Lamghari, M; Buschauer, A; Bernhardt, G Fluorescent H ACS Med Chem Lett 11:1521-1528 (2020) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50543283
Synonyms:
CHEMBL4647775
Type:
Small organic molecule
Emp. Form.:
C61H76F6N6O8
Mol. Mass.:
1135.282
SMILES:
OC(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.C[N+]1=C(\C=C\C=C\C=C2/N(CCCCCC(=O)NCCCCCCNc3c(NCCCOc4cccc(CN5CCCCC5)c4)c(=O)c3=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 |c:13|
Structure:
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