Reaction Details Report a problem with these data
Target
Interleukin-1 receptor antagonist protein
Ligand
BDBM50331042
Substrate
n/a
Meas. Tech.
ChEMBL_1992032 (CHEMBL4625767)
IC50
5.0±n/a nM
Citation
 Mpakali, A; Saridakis, E; Giastas, P; Maben, Z; Stern, LJ; Larhed, M; Hallberg, M; Stratikos, E Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor. ACS Med Chem Lett 11:1429-1434 (2020) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor antagonist protein
Synonyms:
ICIL-1RA | IL-1RN | IL-1ra | IL1 inhibitor | IL1F3 | IL1RA | IL1RA_HUMAN | IL1RN | INN=Anakinra | IRAP | Interleukin-1 receptor antagonist protein
Type:
PROTEIN
Mol. Mass.:
20053.78
Organism:
Homo sapiens
Description:
ChEMBL_118941
Residue:
177
Sequence:
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
  
Inhibitor
Name:
BDBM50331042
Synonyms:
2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,10-dioxo-1,2-dithia-5,9-diazacyclotridecane-4-carboxamido)methyl)phenyl)acetic acid | CHEMBL1277623
Type:
Small organic molecule
Emp. Form.:
C26H32N4O6S2
Mol. Mass.:
560.685
SMILES:
N[C@H]1CCSSC[C@H](NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)NCc1ccccc1CC(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: