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Target
Signal peptide peptidase-like 2B
Ligand
BDBM50546132
Substrate
n/a
Meas. Tech.
ChEMBL_2014332 (CHEMBL4667910)
IC50
270±n/a nM
Citation
 Velcicky, J; Mathison, CJN; Nikulin, V; Pflieger, D; Epple, R; Azimioara, M; Cow, C; Michellys, PY; Rigollier, P; Beisner, DR; Bodendorf, U; Guerini, D; Liu, B; Wen, B; Zaharevitz, S; Brandl, T Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors. ACS Med Chem Lett 10:887-892 (2019) [PubMed]  Article 
Target
Name:
Signal peptide peptidase-like 2B
Synonyms:
3.4.23.- | IMP-4 | IMP4 | Intramembrane protease 4 | KIAA1532 | PSH4 | PSL1 | Presenilin homologous protein 4 | Presenilin-like protein 1 | SPP-like 2B | SPP2B_HUMAN | SPPL2B | Signal peptide peptidase-like 2B | Synonyms=IMP4
Type:
PROTEIN
Mol. Mass.:
64655.18
Organism:
Homo sapiens
Description:
ChEMBL_117517
Residue:
592
Sequence:
MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA
  
Inhibitor
Name:
BDBM50546132
Synonyms:
CHEMBL4759048
Type:
Small organic molecule
Emp. Form.:
C24H31F3N2O4S
Mol. Mass.:
500.574
SMILES:
CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r|
Structure:
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