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Target
Endothelin-1 receptor
Ligand
BDBM50105048
Substrate
n/a
Meas. Tech.
ChEMBL_65802 (CHEMBL679705)
IC50
0.0039±n/a nM
Citation
 Morimoto, H; Shimadzu, H; Kushiyama, E; Kawanishi, H; Hosaka, T; Kawase, Y; Yasuda, K; Kikkawa, K; Yamauchi-Kohno, R; Yamada, K Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. J Med Chem 44:3355-68 (2001) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_PIG | Endothelin receptor ET-A
Type:
PROTEIN
Mol. Mass.:
48707.29
Organism:
Sus scrofa
Description:
ChEMBL_65803
Residue:
427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50105048
Synonyms:
CHEMBL112144 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C27H28BrN5O6S
Mol. Mass.:
630.51
SMILES:
COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ncnc1OCCOc1ncc(Br)cn1
Structure:
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