Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50105470
Substrate
n/a
Meas. Tech.
ChEBML_200992
IC50
4.4±n/a nM
Citation
 Hay, BA; Cole, BM; DiCapua, FM; Kirk, GW; Murray, MC; Nardone, RA; Pelletier, DJ; Ricketts, AP; Robertson, AS; Siegel, TW Small molecule somatostatin receptor subtype-2 antagonists. Bioorg Med Chem Lett 11:2731-4 (2001) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50105470
Synonyms:
(S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(4-methyl-benzoyl)-piperazine-1-carbonyl]-amino}-propionylamino)-hexanoic acid tert-butyl ester | CHEMBL94293
Type:
Small organic molecule
Emp. Form.:
C34H46N6O5
Mol. Mass.:
618.7662
SMILES:
Cc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)OC(C)(C)C
Structure:
Search PDB for entries with ligand similarity: