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Found 112 with Last Name = 'dicapua' and Initial = 'fm'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  0.800nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  1.60nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  2.20nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  2.70nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105466((S)-6-Amino-2-[(R)-2-[(4-benzenesulfonyl-piperazin...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105472((S)-6-Amino-2-[(R)-2-[(1-benzenesulfonyl-piperidin...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  3.80nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105465((4R,8S,11S,17S)-8-(4-Amino-butyl)-17-(2-amino-3-na...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105470((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(4-meth...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105469((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(2-oxo-...)
Affinity DataIC50:  6.5nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105469((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(2-oxo-...)
Affinity DataIC50:  6.5nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105468((S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carb...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105468((S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carb...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105471((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(toluen...)
Affinity DataIC50:  9.20nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  9.80nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  10nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  10.7nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  10.9nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  15.3nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  15.6nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  17.9nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  18nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062379(3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-me...)
Affinity DataIC50:  20.2nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062379(3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-me...)
Affinity DataIC50:  22.2nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  27.2nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105466((S)-6-Amino-2-[(R)-2-[(4-benzenesulfonyl-piperazin...)
Affinity DataIC50:  29nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  31.6nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471675(CHEMBL307678)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  35.7nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471668(CHEMBL309803)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471677(CHEMBL76066)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062379(3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-me...)
Affinity DataIC50:  50.7nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471683(CHEMBL74597)
Affinity DataIC50:  63nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105470((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(4-meth...)
Affinity DataIC50:  67nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  95.2nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105472((S)-6-Amino-2-[(R)-2-[(1-benzenesulfonyl-piperidin...)
Affinity DataIC50:  120nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062379(3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-me...)
Affinity DataIC50:  126nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471680(CHEMBL75247)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471666(CHEMBL308784)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471664(CHEMBL307286)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105465((4R,8S,11S,17S)-8-(4-Amino-butyl)-17-(2-amino-3-na...)
Affinity DataIC50:  270nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471672(CHEMBL75722)
Affinity DataIC50:  270nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471669(CHEMBL305806)
Affinity DataIC50:  420nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471682(CHEMBL75819 | CP-220629)
Affinity DataIC50:  440nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471667(CHEMBL76065)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471662(CHEMBL406941)
Affinity DataIC50:  490nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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