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Target
UDP-glucuronosyltransferase 1A9
Ligand
BDBM50511112
Substrate
n/a
Meas. Tech.
ChEMBL_2016322 (CHEMBL4669900)
IC50
>20000±n/a nM
Citation
 Huard, K; Smith, AC; Cappon, G; Dow, RL; Edmonds, DJ; El-Kattan, A; Esler, WP; Fernando, DP; Griffith, DA; Kalgutkar, AS; Ross, TT; Bagley, SW; Beebe, D; Bi, YA; Cabral, S; Crowley, C; Doran, SD; Dowling, MS; Liras, S; Mascitti, V; Niosi, M; Pfefferkorn, JA; Polivkova, J; Préville, C; Price, DA; Shavnya, A; Shirai, N; Smith, AH; Southers, JR; Tess, DA; Thuma, BA; Varma, MV; Yang, X Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. J Med Chem 63:10879-10896 (2020) [PubMed] 
Target
Name:
UDP-glucuronosyltransferase 1A9
Synonyms:
GNT1 | UD19_HUMAN | UDP-glucuronosyltransferase 1-9 | UDP-glucuronosyltransferase 1-I | UDP-glucuronosyltransferase 1A9 | UDPGT 1-9 | UGT-1I | UGT1 | UGT1*9 | UGT1-09 | UGT1.9 | UGT1A9 | UGT1I | lugP4
Type:
PROTEIN
Mol. Mass.:
59953.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1489266
Residue:
530
Sequence:
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50511112
Synonyms:
CHEMBL4567446
Type:
Small organic molecule
Emp. Form.:
C28H30N4O5
Mol. Mass.:
502.5616
SMILES:
COc1cc(cc(n1)-c1ccc(cc1)C(O)=O)C(=O)N1CCC2(CC1)Cc1cnn(C(C)C)c1C(=O)C2
Structure:
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