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Target
Tubulin beta-2B chain
Ligand
BDBM50107673
Substrate
n/a
Meas. Tech.
ChEMBL_211336 (CHEMBL820779)
IC50
2100±n/a nM
Citation
 Mahboobi, S; Pongratz, H; Hufsky, H; Hockemeyer, J; Frieser, M; Lyssenko, A; Paper, DH; Bürgermeister, J; Böhmer, FD; Fiebig, HH; Burger, AM; Baasner, S; Beckers, T Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem 44:4535-53 (2001) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50107673
Synonyms:
(3-Difluoromethylsulfanyl-phenyl)-(5-methoxy-1H-indol-2-yl)-methanone | CHEMBL140873
Type:
Small organic molecule
Emp. Form.:
C17H13F2NO2S
Mol. Mass.:
333.352
SMILES:
COc1ccc2[nH]c(cc2c1)C(=O)c1cccc(SC(F)F)c1
Structure:
Search PDB for entries with ligand similarity: