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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50549086
Substrate
n/a
Meas. Tech.
ChEMBL_2023916 (CHEMBL4677729)
IC50
9.0±n/a nM
Citation
Yamada, Y; Takashima, H; Walmsley, DL; Ushiyama, F; Matsuda, Y; Kanazawa, H; Yamaguchi-Sasaki, T; Tanaka-Yamamoto, N; Yamagishi, J; Kurimoto-Tsuruta, R; Ogata, Y; Ohtake, N; Angove, H; Baker, L; Harris, R; Macias, A; Robertson, A; Surgenor, A; Watanabe, H; Nakano, K; Mima, M; Iwamoto, K; Okada, A; Takata, I; Hitaka, K; Tanaka, A; Fujita, K; Sugiyama, H; Hubbard, RE Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J Med Chem 63:14805-14820 (2020) [PubMed] Article
More Info.:
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33428.15
Organism:
Pseudomonas aeruginosa
Description:
P47205
Residue:
303
Sequence:
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPAAAV