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Target
Fatty acid CoA ligase Acsl3
Ligand
BDBM50549458
Substrate
n/a
Meas. Tech.
ChEMBL_2024884 (CHEMBL4678697)
IC50
114000±n/a nM
Citation
 Hayashi, K; Kondo, N; Omori, N; Yoshimoto, R; Hato, M; Shigaki, S; Nagasawa, A; Ito, M; Okuno, T Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors. Bioorg Med Chem Lett 33:0 (2021) [PubMed]  Article 
Target
Name:
Fatty acid CoA ligase Acsl3
Synonyms:
6.2.1.15 | 6.2.1.2 | 6.2.1.3 | ACS3 | ACSL3 | ACSL3_HUMAN | Arachidonate--CoA ligase | FACL3 | Fatty acid CoA ligase Acsl3 | LACS 3 | LACS3 | Long-chain acyl-CoA synthetase 3 | Long-chain-fatty-acid--CoA ligase 3 | Medium-chain acyl-CoA ligase Acsl3
Type:
PROTEIN
Mol. Mass.:
80435.82
Organism:
Homo sapiens
Description:
ChEMBL_120091
Residue:
720
Sequence:
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
  
Inhibitor
Name:
BDBM50549458
Synonyms:
CHEMBL4776019
Type:
Small organic molecule
Emp. Form.:
C20H20O5
Mol. Mass.:
340.3698
SMILES:
OC(=O)CCCCCCOc1ccc2oc3ccccc3c(=O)c2c1
Structure:
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