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Target
Histamine H3 receptor
Ligand
BDBM50112017
Substrate
n/a
Meas. Tech.
ChEBML_85849
Ki
22±n/a nM
Citation
 Aslanian, R; Mutahi, MW; Shih, NY; McCormick, KD; Piwinski, JJ; Ting, PC; Albanese, MM; Berlin, MY; Zhu, X; Wong, SC; Rosenblum, SB; Jiang, Y; West, R; She, S; Williams, SM; Bryant, M; Hey, JA Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template. Bioorg Med Chem Lett 12:937-41 (2002) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50112017
Synonyms:
1-(3,5-Bis-trifluoromethyl-phenyl)-3-[4-(1H-imidazol-4-ylmethyl)-benzyl]-urea | CHEMBL173921
Type:
Small organic molecule
Emp. Form.:
C20H16F6N4O
Mol. Mass.:
442.3577
SMILES:
FC(F)(F)c1cc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)cc(c1)C(F)(F)F
Structure:
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