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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM88120
Substrate
n/a
Meas. Tech.
ChEMBL_2047188 (CHEMBL4701887)
IC50
78±n/a nM
Citation
 LaMarche, MJ; Acker, M; Argintaru, A; Bauer, D; Boisclair, J; Chan, H; Chen, CH; Chen, YN; Chen, Z; Deng, Z; Dore, M; Dunstan, D; Fan, J; Fekkes, P; Firestone, B; Fodor, M; Garcia-Fortanet, J; Fortin, PD; Fridrich, C; Giraldes, J; Glick, M; Grunenfelder, D; Hao, HX; Hentemann, M; Ho, S; Jouk, A; Kang, ZB; Karki, R; Kato, M; Keen, N; Koenig, R; LaBonte, LR; Larrow, J; Liu, G; Liu, S; Majumdar, D; Mathieu, S; Meyer, MJ; Mohseni, M; Ntaganda, R; Palermo, M; Perez, L; Pu, M; Ramsey, T; Reilly, J; Sarver, P; Sellers, WR; Sendzik, M; Shultz, MD; Slisz, J; Slocum, K; Smith, T; Spence, S; Stams, T; Straub, C; Tamez, V; Toure, BB; Towler, C; Wang, P; Wang, H; Williams, SL; Yang, F; Yu, B; Zhang, JH; Zhu, S Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J Med Chem 63:13578-13594 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM88120
Synonyms:
US10245267, Example 1156 | US10709712, Example 1156 | US9694016, 1156
Type:
Small organic molecule
Emp. Form.:
C25H25F3N4O4
Mol. Mass.:
502.4856
SMILES:
Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCO)nc(c1)N1CCOCC1
Structure:
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