Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50120764
Substrate
n/a
Meas. Tech.
ChEMBL_29129 (CHEMBL642433)
Ki
17±n/a nM
Citation
 Novellino, E; Abignente, E; Cosimelli, B; Greco, G; Iadanza, M; Laneri, S; Lavecchia, A; Rimoli, MG; Settimo, FD; Primofiore, G; Tuscano, D; Trincavelli, L; Martini, C Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists. J Med Chem 45:5030-6 (2002) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36602.99
Organism:
BOVINE
Description:
ADENOSINE 0 BOVINE::P28190
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPVDEDAPAERPDD
  
Inhibitor
Name:
BDBM50120764
Synonyms:
CHEMBL149732 | Cyclopentanecarboxylic acid (2,7-diphenyl-imidazo[1,2-a][1,3,5]triazin-4-yl)-amide
Type:
Small organic molecule
Emp. Form.:
C23H21N5O
Mol. Mass.:
383.4457
SMILES:
O=C(Nc1nc(nc2nc(cn12)-c1ccccc1)-c1ccccc1)C1CCCC1
Structure:
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