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Target
Caspase-1
Ligand
BDBM50145661
Substrate
n/a
Meas. Tech.
ChEBML_46513
IC50
27±n/a nM
Citation
 Linton, SD; Aja, T; Allegrini, PR; Deckwerth, TL; Diaz, JL; Hengerer, B; Herrmann, J; Jahangiri, KG; Kallen, J; Karanewsky, DS; Meduna, SP; Nalley, K; Robinson, ED; Roggo, S; Rovelli, G; Sauter, A; Sayers, RO; Schmitz, A; Smidt, R; Ternansky, RJ; Tomaselli, KJ; Ullman, BR; Wiessner, C; Wu, JC Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke. Bioorg Med Chem Lett 14:2685-91 (2004) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
CASP1_MOUSE | Casp1 | Il1bc
Type:
PROTEIN
Mol. Mass.:
45636.44
Organism:
Mus musculus
Description:
ChEMBL_651546
Residue:
402
Sequence:
MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNKEDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQEGICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
  
Inhibitor
Name:
BDBM50145661
Synonyms:
(S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl)-amino]-pentanoylamino}-4-oxo-butyric acid | CHEMBL90307
Type:
Small organic molecule
Emp. Form.:
C22H25N3O6
Mol. Mass.:
427.4504
SMILES:
CC(C)C[C@H](NC(=O)C(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(O)=O)C=O
Structure:
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