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Target
C-C chemokine receptor type 2
Ligand
BDBM50153918
Substrate
n/a
Meas. Tech.
ChEMBL_305948 (CHEMBL832788)
IC50
28000±n/a nM
Citation
 Imai, M; Shiota, T; Kataoka, K; Tarby, CM; Moree, WJ; Tsutsumi, T; Sudo, M; Ramirez-Weinhouse, MM; Comer, D; Sun, CM; Yamagami, S; Tanaka, H; Morita, T; Hada, T; Greene, J; Barnum, D; Saunders, J; Myers, PL; Kato, Y; Endo, N Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. Bioorg Med Chem Lett 14:5407-11 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50153918
Synonyms:
CHEMBL362889 | Thiophene-2-carboxylic acid N''-(2-{4-[3-hydroxy-3-(3-hydroxy-phenyl)-3-phenyl-propyl]-[1,4]diazepan-1-yl}-acetyl)-hydrazide
Type:
Small organic molecule
Emp. Form.:
C27H32N4O4S
Mol. Mass.:
508.632
SMILES:
Oc1cccc(c1)C(O)(CCN1CCCN(CC(=O)NNC(=O)c2cccs2)CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: