Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50153926
Substrate
n/a
Meas. Tech.
ChEMBL_305948 (CHEMBL832788)
IC50
7400±n/a nM
Citation
 Imai, M; Shiota, T; Kataoka, K; Tarby, CM; Moree, WJ; Tsutsumi, T; Sudo, M; Ramirez-Weinhouse, MM; Comer, D; Sun, CM; Yamagami, S; Tanaka, H; Morita, T; Hada, T; Greene, J; Barnum, D; Saunders, J; Myers, PL; Kato, Y; Endo, N Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. Bioorg Med Chem Lett 14:5407-11 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50153926
Synonyms:
4-Methyl-thiophene-2-carboxylic acid N''-{2-[4-(4-chloro-benzyl)-[1,4]diazepan-1-yl]-acetyl}-hydrazide | CHEMBL186855
Type:
Small organic molecule
Emp. Form.:
C20H25ClN4O2S
Mol. Mass.:
420.956
SMILES:
Cc1csc(c1)C(=O)NNC(=O)CN1CCCN(Cc2ccc(Cl)cc2)CC1
Structure:
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