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Target
Neuropeptide S receptor
Ligand
BDBM50443391
Substrate
n/a
Meas. Tech.
ChEMBL_2170613 (CHEMBL5055747)
Ki
48±n/a nM
Citation
 Albanese, V; Ruzza, C; Marzola, E; Bernardi, T; Fabbri, M; Fantinati, A; Trapella, C; Reinscheid, RK; Ferrari, F; Sturaro, C; Calò, G; Amendola, G; Cosconati, S; Pacifico, S; Guerrini, R; Preti, D Structure-Activity Relationship Studies on Oxazolo[3,4- J Med Chem 64:4089-4108 (2021) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50443391
Synonyms:
CHEMBL469695
Type:
Small organic molecule
Emp. Form.:
C26H24FN3O3
Mol. Mass.:
445.4855
SMILES:
Fc1ccc(CNC(=O)N2CCN3C(C2)C(OC3=O)(c2ccccc2)c2ccccc2)cc1
Structure:
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