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Target
REST corepressor 1
Ligand
BDBM50594099
Substrate
n/a
Meas. Tech.
ChEMBL_2210855 (CHEMBL5123804)
Ki
175±n/a nM
Citation
 Menna, M; Fiorentino, F; Marrocco, B; Lucidi, A; Tomassi, S; Cilli, D; Romanenghi, M; Cassandri, M; Pomella, S; Pezzella, M; Del Bufalo, D; Zeya Ansari, MS; Toma?evi?, N; Mladenovi?, M; Viviano, M; Sbardella, G; Rota, R; Trisciuoglio, D; Minucci, S; Mattevi, A; Rotili, D; Mai, A Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
REST corepressor 1
Synonyms:
KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1
Type:
PROTEIN
Mol. Mass.:
53329.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108118
Residue:
485
Sequence:
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS
  
Inhibitor
Name:
BDBM50594099
Synonyms:
CHEMBL5186174
Type:
Small organic molecule
Emp. Form.:
C29H42N6O2
Mol. Mass.:
506.6828
SMILES:
CCN(CC)CCCNc1nc(NC2CCN(Cc3ccccc3)CC2)c2cc(OC)c(OC)cc2n1
Structure:
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