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Target
NUAK family SNF1-like kinase 1
Ligand
BDBM50598717
Substrate
n/a
Meas. Tech.
ChEMBL_2227785 (CHEMBL5141298)
IC50
25±n/a nM
Citation
 Li, S; Si, H; Song, X; Lei, C; He, X; Wang, J; Liu, Y; Zhou, Y; Song, JG; Peng, L; Tang, X; Chan, S; Ren, X; Tu, Z; Li, Z; Wang, Z; Zhang, Z; Ding, K Discovery of Hexahydrofuro[3,2- J Med Chem 65:10674-10690 (2022) [PubMed] 
Target
Name:
NUAK family SNF1-like kinase 1
Synonyms:
ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1
Type:
PROTEIN
Mol. Mass.:
74326.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451343
Residue:
661
Sequence:
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN
  
Inhibitor
Name:
BDBM50598717
Synonyms:
CHEMBL5193702 | US20230348487, Example LS 6-45
Type:
Small organic molecule
Emp. Form.:
C25H33ClN6O5
Mol. Mass.:
533.02
SMILES:
[H][C@]12OC[C@@H](Oc3nc(Nc4ccc(N(C)CCN(C)C)c(NC(=O)C=C)c4)ncc3Cl)[C@@]1([H])OC[C@H]2OC |r|
Structure:
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