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Target
Proteinase-activated receptor 4
Ligand
BDBM176258
Substrate
n/a
Meas. Tech.
ChEMBL_2234808 (CHEMBL5148580)
IC50
0.600000±n/a nM
Citation
 Priestley, ES; Banville, J; Deon, D; Dubé, L; Gagnon, M; Guy, J; Lapointe, P; Lavallée, JF; Martel, A; Plamondon, S; Rémillard, R; Ruediger, E; Tremblay, F; Posy, SL; Guarino, VR; Richter, JM; Li, J; Gupta, A; Vetrichelvan, M; Balapragalathan, TJ; Mathur, A; Hua, J; Callejo, M; Guay, J; Sum, CS; Cvijic, ME; Watson, C; Wong, P; Yang, J; Bouvier, M; Gordon, DA; Wexler, RR; Marinier, A Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. J Med Chem 65:8843-8854 (2022) [PubMed] 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM176258
Synonyms:
US10047103, 291 | US9688695, 291
Type:
Small organic molecule
Emp. Form.:
C29H23F2N5O5S2
Mol. Mass.:
623.65
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)N3CCC(F)(F)C3)cc(OC)cc2o1
Structure:
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