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Target
Mu-type opioid receptor
Ligand
BDBM50188217
Substrate
n/a
Meas. Tech.
ChEMBL_379860 (CHEMBL864843)
IC50
13±n/a nM
Citation
 Nefzi, A; Ostresh, JM; Appel, JR; Bidlack, J; Dooley, CT; Houghten, RA Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. Bioorg Med Chem Lett 16:4331-8 (2006) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50188217
Synonyms:
4-[(2S)-3-{[(2S)-1-{[(2S)-1-[(2S)-2-(aminomethyl)pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]amino}-3-(4-hydroxyphenyl)propan-2-yl]amino}-2-(ethylamino)propyl]phenol | CHEMBL213268
Type:
Small organic molecule
Emp. Form.:
C34H49N5O3
Mol. Mass.:
575.7846
SMILES:
CCN[C@H](CN[C@H](CN[C@H](CN1CCC[C@H]1CN)Cc1ccc(O)cc1)Cc1ccc(O)cc1)Cc1ccc(O)cc1
Structure:
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