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Target
Histone deacetylase
Ligand
BDBM50195614
Substrate
n/a
Meas. Tech.
ChEMBL_416719 (CHEMBL909985)
IC50
31±n/a nM
Citation
 Mai, A; Massa, S; Rotili, D; Simeoni, S; Ragno, R; Botta, G; Nebbioso, A; Miceli, M; Altucci, L; Brosch, G Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J Med Chem 49:6046-56 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
Histone deacetylase HD1B
Type:
PROTEIN
Mol. Mass.:
50930.01
Organism:
Zea mays
Description:
ChEMBL_422128
Residue:
458
Sequence:
MAASGEGVSLPSPAGGEDAHRRRVSYFYEPSIGDYYYGQGHPMKPHRIRMAHSLVVHYGLHRLLELSRPYPASEADIRRFHSDDYVAFLASATGNPGVLDPRAIKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKFHRRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVPLSDGIDDTTFRGLFQCIIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRFLRSYNVPMMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNDYYEYFGPDYTLHIQPKSVENLNTTKDLENIKNMILENLSKIEHVPSTQFHDRPSDPEAPEEKEEDMDKRPPQRSRLWSGGAYDSDTEDPDSLKSEGKDVTANFQMKDEPKDDL
  
Inhibitor
Name:
BDBM50195614
Synonyms:
CHEMBL216064 | N-hydroxy-6-[(3,4-dihydro-4-oxo-6-(1-phenylpropyl)-2-pyrimidinylthio]hexanamide
Type:
Small organic molecule
Emp. Form.:
C19H25N3O3S
Mol. Mass.:
375.485
SMILES:
CCC(c1ccccc1)c1cc(=O)[nH]c(SCCCCCC(=O)NO)n1
Structure:
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