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Target
Polyphenol oxidase 2
Ligand
BDBM50197243
Substrate
n/a
Meas. Tech.
ChEMBL_453186 (CHEMBL902336)
IC50
2950±n/a nM
Citation
 Song, S; Lee, H; Jin, Y; Ha, YM; Bae, S; Chung, HY; Suh, H Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. Bioorg Med Chem Lett 17:461-4 (2007) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50197243
Synonyms:
5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol | 5-(6-hydroxynaphthalen-2-yl)benzene-1,2,3-triol | CHEMBL246045
Type:
Small organic molecule
Emp. Form.:
C16H12O4
Mol. Mass.:
268.2641
SMILES:
Oc1ccc2cc(ccc2c1)-c1cc(O)c(O)c(O)c1
Structure:
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