Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 1
Ligand
BDBM50211652
Substrate
n/a
Meas. Tech.
ChEMBL_455638 (CHEMBL903636)
IC50
>20000±n/a nM
Citation
 Yamamoto, T; Fujita, K; Asari, S; Chiba, A; Kataba, Y; Ohsumi, K; Ohmuta, N; Iida, Y; Ijichi, C; Iwayama, S; Fukuchi, N; Shoji, M Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. Bioorg Med Chem Lett 17:3736-40 (2007) [PubMed]  Article 
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
Edg2 | Gpcr91 | LPAR1_RAT | Lpa1 | Lpar1 | Lysophosphatidic acid receptor 1/lysophosphatidic acid receptor 3 | Lysophosphatidic acid receptor Edg-2
Type:
PROTEIN
Mol. Mass.:
41130.42
Organism:
Rattus norvegicus
Description:
ChEMBL_329844
Residue:
364
Sequence:
MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM50211652
Synonyms:
3-{2'-[1-(2-chloro-phenyl)-ethoxycarbonylamino]-biphenyl-4-ylmethylsulfanyl}-propionic acid | CHEMBL245895
Type:
Small organic molecule
Emp. Form.:
C25H24ClNO4S
Mol. Mass.:
469.98
SMILES:
CC(OC(=O)Nc1ccccc1-c1ccc(CSCCC(O)=O)cc1)c1ccccc1Cl
Structure:
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