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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50218671
Substrate
n/a
Meas. Tech.
ChEMBL_457103 (CHEMBL924479)
Ki
2.06±n/a nM
Citation
 Vercouillie, J; Deuther-Conrad, W; Scheunemann, M; Emond, P; Fischer, S; Funke, U; Steinbach, J; Guilloteau, D; Brust, P New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET. Bioorg Med Chem Lett 17:4991-5 (2007) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50218671
Synonyms:
2-(4-chloro-2-((dimethylamino)methyl)phenoxy)-5-fluorobenzenamine | CHEMBL245913
Type:
Small organic molecule
Emp. Form.:
C15H16ClFN2O
Mol. Mass.:
294.752
SMILES:
CN(C)Cc1cc(Cl)ccc1Oc1ccc(F)cc1N
Structure:
Search PDB for entries with ligand similarity: