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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM50252782
Substrate
n/a
Meas. Tech.
ChEMBL_534761 (CHEMBL986285)
IC50
954±n/a nM
Citation
 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J Med Chem 51:6271-9 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM50252782
Synonyms:
CHEMBL493671 | N-Cyclopropyl-4-methyl-3-(1-((S)-2,2,2-trifluoro-1-methylethoxy)-6-phthalazinyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C22H20F3N3O2
Mol. Mass.:
415.4083
SMILES:
C[C@H](Oc1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1)C(F)(F)F |r|
Structure:
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