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Target
Beta-3 adrenergic receptor
Ligand
BDBM50275223
Substrate
n/a
Meas. Tech.
ChEMBL_494295 (CHEMBL938627)
IC50
1180±n/a nM
Citation
 Shakya, N; Roy, KK; Saxena, AK Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as beta3-adrenergic receptor agonists: design, synthesis, biological evaluation and pharmacophore modeling. Bioorg Med Chem 17:830-47 (2009) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50275223
Synonyms:
1-(1-Benzyl-1,2,3,4-tetrahydroquinolin-6-yloxy)-3-[2-(4-methoxyphenyl)ethylamino]propan-2-ol | CHEMBL530556
Type:
Small organic molecule
Emp. Form.:
C28H34N2O3
Mol. Mass.:
446.5812
SMILES:
COc1ccc(CCNCC(O)COc2ccc3N(Cc4ccccc4)CCCc3c2)cc1
Structure:
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