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Found 264 with Last Name = 'saxena' and Initial = 'ak'
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477152(CHEMBL393466)
Affinity DataKi:  0.643nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50202762(CHEMBL238952 | N-(4-(3-(4-m-tolylpiperazin-1-yl)pr...)
Affinity DataKi:  6.09nMAssay Description:Displacement of [3H]ketanserin from rat cloned 5HT2A receptor expressed in NIH-3T3-GF6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477152(CHEMBL393466)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50133931(1-(4-fluoro-phenyl)-4-(3,4,6,7,12,12a-hexahydro-1H...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50202763(1-(3-(phenylthio)propyl)-4-m-tolylpiperazine | CHE...)
Affinity DataKi:  13.6nMAssay Description:Displacement of [3H]ketanserin from rat cloned 5HT2A receptor expressed in NIH-3T3-GF6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50202764(1-(3-(4-nitrophenylthio)propyl)-4-m-tolylpiperazin...)
Affinity DataKi:  21.1nMAssay Description:Displacement of [3H]ketanserin from rat cloned 5HT2A receptor expressed in NIH-3T3-GF6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50202761(CHEMBL239371 | N-(4-(3-(4-o-tolylpiperazin-1-yl)pr...)
Affinity DataKi:  21.1nMAssay Description:Displacement of [3H]ketanserin from rat cloned 5HT2A receptor expressed in NIH-3T3-GF6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50133931(1-(4-fluoro-phenyl)-4-(3,4,6,7,12,12a-hexahydro-1H...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477151(CHEMBL393622)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477151(CHEMBL393622)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50133931(1-(4-fluoro-phenyl)-4-(3,4,6,7,12,12a-hexahydro-1H...)
Affinity DataKi:  425nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477152(CHEMBL393466)
Affinity DataKi:  2.25E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24524((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-metho...)
Affinity DataKi:  1.17E+4nM ΔG°:  -28.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24516((2E,5E)-5-[(4-methoxyphenyl)methylidene]-2-(1,3-th...)
Affinity DataKi:  1.17E+4nM ΔG°:  -28.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24523((2E,5E)-2-{[4-(adamantan-1-yl)-1,3-thiazol-2-yl]im...)
Affinity DataKi:  1.23E+4nM ΔG°:  -28.0kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24526((2E,5E)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylid...)
Affinity DataKi:  1.29E+4nM ΔG°:  -27.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24527((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-nitro...)
Affinity DataKi:  1.62E+4nM ΔG°:  -27.3kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24525((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-hydro...)
Affinity DataKi:  1.81E+4nM ΔG°:  -27.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24529((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...)
Affinity DataKi:  2.28E+4nM ΔG°:  -26.5kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24515((2E,5E)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]...)
Affinity DataKi:  2.56E+4nM ΔG°:  -26.2kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24528((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(3-nitro...)
Affinity DataKi:  2.87E+4nM ΔG°:  -25.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24521((2E,5E)-5-[(2-chlorophenyl)methylidene]-2-(1,3-thi...)
Affinity DataKi:  3.23E+4nM ΔG°:  -25.6kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24519((2E,5E)-5-[(4-chlorophenyl)methylidene]-2-(1,3-thi...)
Affinity DataKi:  5.45E+4nM ΔG°:  -24.3kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24530((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-hydro...)
Affinity DataKi:  9.08E+4nM ΔG°:  -23.1kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477150(CHEMBL240733)
Affinity DataKi: <1.00E+5nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50477150(CHEMBL240733)
Affinity DataKi: <1.00E+5nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24522((2E,5E)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]...)
Affinity DataKi:  1.03E+5nM ΔG°:  -22.8kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24513((2E,5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-th...)
Affinity DataKi:  3.88E+5nM ΔG°:  -19.5kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24517((2E,5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataKi:  4.74E+5nM ΔG°:  -19.0kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24518((2E,5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thia...)
Affinity DataKi:  5.48E+5nM ΔG°:  -18.6kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM24520((2E,5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thi...)
Affinity DataKi:  1.09E+6nM ΔG°:  -16.9kJ/molepH: 7.0 T: 2°CAssay Description:SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.11E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418564(CHEMBL423026)
Affinity DataKi:  1.12E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  1.13E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418576(CHEMBL1785077)
Affinity DataKi:  1.18E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418568(CHEMBL146822)
Affinity DataKi:  1.18E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418563(CHEMBL148301)
Affinity DataKi:  1.20E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418575(CHEMBL358137)
Affinity DataKi:  1.20E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418571(CHEMBL346219)
Affinity DataKi:  1.22E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418557(CHEMBL1785028)
Affinity DataKi:  1.26E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418565(CHEMBL1785075)
Affinity DataKi:  1.32E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418566(CHEMBL146322)
Affinity DataKi:  1.32E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418573(CHEMBL147694)
Affinity DataKi:  1.33E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418562(CHEMBL357479)
Affinity DataKi:  1.37E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50418567(CHEMBL148060)
Affinity DataKi:  1.41E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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