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Target
Histone deacetylase 8
Ligand
BDBM50250151
Substrate
n/a
Meas. Tech.
ChEMBL_498747 (CHEMBL1021939)
IC50
>100000±n/a nM
Citation
 Suzuki, N; Suzuki, T; Ota, Y; Nakano, T; Kurihara, M; Okuda, H; Yamori, T; Tsumoto, H; Nakagawa, H; Miyata, N Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. J Med Chem 52:2909-22 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50250151
Synonyms:
(R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-carbonylamino)heptylboronic acid | CHEMBL492174
Type:
Small organic molecule
Emp. Form.:
C23H26BN3O4S
Mol. Mass.:
451.346
SMILES:
OB(O)CCCCC[C@@H](NC(=O)c1cncs1)C(=O)Nc1cccc(c1)-c1ccccc1 |r|
Structure:
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