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Found 121 with Last Name = 'nakano' and Initial = 't'
TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250101((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-car...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant HDAC2 by fluorometryMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250099((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-car...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human recombinant HDAC1 by fluorometryMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250101((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-car...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant HDAC2 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250099((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-car...)
Affinity DataIC50:  830nMAssay Description:Inhibition of human recombinant HDAC2 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50249973((S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493633(CHEMBL2437434)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant HDAC8 by fluorometryMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250101((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-car...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant HDAC1 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250099((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-car...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human recombinant HDAC1 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493644(CHEMBL2437437)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493654(CHEMBL2437444)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50249973((S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human recombinant HDAC2 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493647(CHEMBL2437436)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397271(CHEMBL2169933)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250151((R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-car...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493635(CHEMBL2437441)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250101((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-car...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human recombinant HDAC8 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493650(CHEMBL2437443)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493634(CHEMBL2437438)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493637(CHEMBL2437446)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397246(CHEMBL2172802)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493643(CHEMBL2437442)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50249973((S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC1 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397253(CHEMBL2172795)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397248(CHEMBL2172800)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493655(CHEMBL2437439)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397255(CHEMBL2172793)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250100((R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-car...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397252(CHEMBL2172796)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397262(CHEMBL2169942)
Affinity DataIC50:  1.41E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397254(CHEMBL2172794)
Affinity DataIC50:  1.43E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397247(CHEMBL2172801)
Affinity DataIC50:  1.49E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493649(CHEMBL2434994)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397265(CHEMBL2169939)
Affinity DataIC50:  1.71E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493641(CHEMBL2437454)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397274(CHEMBL2169930)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397244(CHEMBL2172804)
Affinity DataIC50:  2.06E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493636(CHEMBL2437440)
Affinity DataIC50:  2.08E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50491275(CHEMBL2381680)
Affinity DataIC50:  2.22E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250099((S)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-car...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human recombinant HDAC8 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50397249(CHEMBL2172799)
Affinity DataIC50:  2.32E+4nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50493648(CHEMBL2437445)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coli BL21(DE3) using Biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 1 hr by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50250098((R)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human recombinant HDAC6 by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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