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Target
DNA polymerase beta
Ligand
BDBM50250356
Substrate
n/a
Meas. Tech.
ChEMBL_546495 (CHEMBL1026664)
IC50
7400±n/a nM
Citation
 Pengsuparp, T; Cai, L; Constant, H; Fong, HH; Lin, LZ; Kinghorn, AD; Pezzuto, JM; Cordell, GA; Ingolfsdöttir, K; Wagner, H; Hughes, SH Mechanistic Evaluation of New Plant-Derived Compounds That Inhibit HIV-1 Reverse Transcriptase J Nat Prod 58:1024-1031 (1995) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50250356
Synonyms:
(+)-protolichesterinic acid | CHEMBL490329 | protolichesterinic acid
Type:
Small organic molecule
Emp. Form.:
C19H32O4
Mol. Mass.:
324.455
SMILES:
CCCCCCCCCCCCC[C@@H]1OC(=O)C(=C)[C@H]1C(O)=O |r|
Structure:
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