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Target
N-formyl peptide receptor 3
Ligand
BDBM50295513
Substrate
n/a
Meas. Tech.
ChEMBL_580003 (CHEMBL1051691)
EC50
10±n/a nM
Citation
 Cilibrizzi, A; Quinn, MT; Kirpotina, LN; Schepetkin, IA; Holderness, J; Ye, RD; Rabiet, MJ; Biancalani, C; Cesari, N; Graziano, A; Vergelli, C; Pieretti, S; Dal Piaz, V; Giovannoni, MP 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. J Med Chem 52:5044-57 (2010) [PubMed]  Article 
Target
Name:
N-formyl peptide receptor 3
Synonyms:
FML2_HUMAN | FPR3 | FPR3_HUMAN | FPRH1 | FPRL2
Type:
PROTEIN
Mol. Mass.:
39971.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_580003
Residue:
353
Sequence:
METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNFAFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
  
Inhibitor
Name:
BDBM50295513
Synonyms:
(S)-6-amino-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-N-((5R,8S,11S,14S)-5-carbamoyl-15-(4-hydroxyphenyl)-8-isopropyl-11-(2-(methylthio)ethyl)-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-14-yl)hexanamide | CHEMBL552527
Type:
Small organic molecule
Emp. Form.:
C41H61N9O7S2
Mol. Mass.:
856.109
SMILES:
CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O |r|
Structure:
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