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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50295873
Substrate
n/a
Meas. Tech.
ChEMBL_578767 (CHEMBL1052340)
IC50
1900±n/a nM
Citation
 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. Bioorg Med Chem 17:4420-4 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK-2 | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | MAP kinase 2 | MAPK 2 | MK01_RAT | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42-MAPK
Type:
Enzyme
Mol. Mass.:
41278.65
Organism:
Rattus norvegicus (rat)
Description:
MAP Kinase is the rat ERK-2 isoform containing a polyhistidine tag at the N-terminus produced in E.coli. and activated by phosphorylation with MEK1 prior to purification.
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50295873
Synonyms:
4-[2-Amino-4-(1H-indol-3-yl)pyrimidin-5-yl]benzamide | CHEMBL559591
Type:
Small organic molecule
Emp. Form.:
C19H15N5O
Mol. Mass.:
329.3553
SMILES:
NC(=O)c1ccc(cc1)-c1cnc(N)nc1-c1c[nH]c2ccccc12
Structure:
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