Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50297774
Substrate
n/a
Meas. Tech.
ChEMBL_584072 (CHEMBL1058313)
EC50
1700±n/a nM
Citation
 Ishikawa, M; Nonoshita, K; Ogino, Y; Nagae, Y; Tsukahara, D; Hosaka, H; Maruki, H; Ohyama, S; Yoshimoto, R; Sasaki, K; Nagata, Y; Eiki, J; Nishimura, T Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. Bioorg Med Chem Lett 19:4450-4 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50297774
Synonyms:
1-(2-(5-(4-methoxyphenoxy)-2-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)pyrrolidin-1-yl)ethanone | CHEMBL552083
Type:
Small organic molecule
Emp. Form.:
C25H24N4O3
Mol. Mass.:
428.4831
SMILES:
COc1ccc(Oc2cc3[nH]c(nc3cc2C2CCCN2C(C)=O)-c2ccccn2)cc1
Structure:
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