Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50304380
Substrate
n/a
Meas. Tech.
ChEMBL_602874 (CHEMBL1038417)
EC50
120±n/a nM
Citation
 Takahashi, K; Hashimoto, N; Nakama, C; Kamata, K; Sasaki, K; Yoshimoto, R; Ohyama, S; Hosaka, H; Maruki, H; Nagata, Y; Eiki, J; Nishimura, T The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem 17:7042-51 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50304380
Synonyms:
5-[4-(Ethylsulfonyl)phenoxy]-6-(1H-imidazol-1-ylmethyl)-2-(pyridin-2-yl)-1H-benzimidazole | CHEMBL594382
Type:
Small organic molecule
Emp. Form.:
C24H21N5O3S
Mol. Mass.:
459.52
SMILES:
CCS(=O)(=O)c1ccc(Oc2cc3[nH]c(nc3cc2Cn2ccnc2)-c2ccccn2)cc1
Structure:
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