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Target
Histamine H3 receptor
Ligand
BDBM50309851
Substrate
n/a
Meas. Tech.
ChEMBL_611486 (CHEMBL1069468)
Ki
15±n/a nM
Citation
 Cole, DC; Gross, JL; Comery, TA; Aschmies, S; Hirst, WD; Kelley, C; Kim, JI; Kubek, K; Ning, X; Platt, BJ; Robichaud, AJ; Solvibile, WR; Stock, JR; Tawa, G; Williams, MJ; Ellingboe, JW Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists. Bioorg Med Chem Lett 20:1237-40 (2010) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50309851
Synonyms:
(S)-1,3'-bipyrrolidin-1'-yl(4-((1H-indol-1-yl)methyl)phenyl)methanone | CHEMBL602515
Type:
Small organic molecule
Emp. Form.:
C24H27N3O
Mol. Mass.:
373.4907
SMILES:
O=C(N1CC[C@@H](C1)N1CCCC1)c1ccc(Cn2ccc3ccccc23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: