Reaction Details Report a problem with these data
Target
Serine palmitoyltransferase 1
Ligand
BDBM50325998
Substrate
n/a
Meas. Tech.
ChEMBL_660503 (CHEMBL1250174)
IC50
10±n/a nM
Citation
Sakamoto, H; Okamoto, K; Aoki, M; Kato, H; Katsume, A; Ohta, A; Tsukuda, T; Shimma, N; Aoki, Y; Arisawa, M; Kohara, M; Sudoh, M Host sphingolipid biosynthesis as a target for hepatitis C virus therapy. Nat Chem Biol 1:333-7 (2006) [PubMed] Article
More Info.:
Target
Name:
Serine palmitoyltransferase 1
Synonyms:
LCB 1 | LCB1 | Long chain base biosynthesis protein 1 | SPT 1 | SPT1 | SPTC1_HUMAN | SPTLC1 | Serine-palmitoyl-CoA transferase 1
Type:
PROTEIN
Mol. Mass.:
52739.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_660503
Residue:
473
Sequence:
MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEELIEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
Inhibitor
Name:
BDBM50325998
Synonyms:
(S)-2-((S,E)-1-((S)-1-carboxy-2-(4-(3-methylbut-2-enyloxy)phenyl)ethylamino)-1,11-dioxooctadec-3-en-2-yl)-2-hydroxysuccinic acid | CHEMBL1241090
Type:
Small organic molecule
Emp. Form.:
C36H53NO10
Mol. Mass.:
659.8067
SMILES:
[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]\[#6@H](-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])cc1)-[#6](-[#8])=O)[C@@]([#8])([#6]-[#6](-[#8])=O)[#6](-[#8])=O |r|