Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50326436
Substrate
n/a
Meas. Tech.
ChEMBL_658036 (CHEMBL1248948)
IC50
6.8±n/a nM
Citation
 Akué-Gédu, R; Nauton, L; Théry, V; Bain, J; Cohen, P; Anizon, F; Moreau, P Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. Bioorg Med Chem 18:6865-73 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50326436
Synonyms:
6-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL1240961
Type:
Small organic molecule
Emp. Form.:
C15H9BrN2O
Mol. Mass.:
313.149
SMILES:
Brc1cccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c12
Structure:
Search PDB for entries with ligand similarity: