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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50326438
Substrate
n/a
Meas. Tech.
ChEMBL_657899 (CHEMBL1248423)
IC50
6±n/a nM
Citation
 Akué-Gédu, R; Nauton, L; Théry, V; Bain, J; Cohen, P; Anizon, F; Moreau, P Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. Bioorg Med Chem 18:6865-73 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50326438
Synonyms:
9-trifluoromethyl-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL1243129
Type:
Small organic molecule
Emp. Form.:
C16H9F3N2O
Mol. Mass.:
302.2507
SMILES:
FC(F)(F)c1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12
Structure:
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