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Target
Neuronal acetylcholine receptor; alpha9/alpha10
Ligand
BDBM50339935
Substrate
n/a
Meas. Tech.
ChEMBL_740890 (CHEMBL1763991)
IC50
4.8±n/a nM
Citation
 Zheng, G; Zhang, Z; Dowell, C; Wala, E; Dwoskin, LP; Holtman, JR; McIntosh, JM; Crooks, PA Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. Bioorg Med Chem Lett 21:2476-9 (2011) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor; alpha9/alpha10
Synonyms:
Neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit | Neuronal acetylcholine receptor subunit alpha-10/alpha-9
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 2150170
Components:
This complex has 2 components.
Component 1
Name:
Neuronal acetylcholine receptor subunit alpha-9
Synonyms:
ACHA9_HUMAN | CHRNA9 | NACHR alpha-9 | NACHRA9 | Neuronal acetylcholine receptor protein alpha-9 subunit | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha-9
Type:
PROTEIN
Mol. Mass.:
54806.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306102
Residue:
479
Sequence:
MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
  
Component 2
Name:
Neuronal acetylcholine receptor subunit alpha-10
Synonyms:
ACH10_HUMAN | CHRNA10 | NACHRA10 | Neuronal acetylcholine receptor protein alpha-10 subunit
Type:
PROTEIN
Mol. Mass.:
49714.45
Organism:
Homo sapiens (Human)
Description:
EBI_12740
Residue:
450
Sequence:
MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
  
Inhibitor
Name:
BDBM50339935
Synonyms:
1,1',1''-(5,5',5''-(benzene-1,3,5-triyl)tris(pentane-5,1-diyl))triquinoliniumbromide | 1-(5-{3,5-bis[5-(quinolin-1-ium-1-yl)pentyl]phenyl}pentyl)quinolin-1-ium tribromide | CHEMBL268074
Type:
Small organic molecule
Emp. Form.:
C48H54N3
Mol. Mass.:
672.9608
SMILES:
C(CCc1cc(CCCCC[n+]2cccc3ccccc23)cc(CCCCC[n+]2cccc3ccccc23)c1)CC[n+]1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: