Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50011700
Substrate
n/a
Meas. Tech.
ChEMBL_195927 (CHEMBL803396)
pH
7.4±n/a
IC50
157±n/a nM
Comments
extracted
Citation
Williams, PD; Perlow, DS; Payne, LS; Holloway, MK; Siegl, PK; Schorn, TW; Lynch, RJ; Doyle, JJ; Strouse, JF; Vlasuk, GP Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics. J Med Chem 34:887-900 (1991) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50011700
Synonyms:
Acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-3-cyclohexyl-1-hydroxy-propyl}-1-methyl-5-oxo-pyrrolidin-2-ylmethyl ester | CHEMBL170289
Type:
Small organic molecule
Emp. Form.:
C37H54N6O8
Mol. Mass.:
710.8601
SMILES:
CN1[C@H](COC(C)=O)C[C@@H]([C@H](O)[C@H](CC2CCCCC2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C1=O