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Target
Substance-P receptor
Ligand
BDBM50002372
Substrate
n/a
Meas. Tech.
ChEMBL_208658 (CHEMBL813318)
IC50
>10000±n/a nM
Citation
 Venepalli, BR; Aimone, LD; Appell, KC; Bell, MR; Dority, JA; Goswami, R; Hall, PL; Kumar, V; Lawrence, KB; Logan, ME Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles. J Med Chem 35:374-8 (1992) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50002372
Synonyms:
1,2,3,4-tetrahydrobenzo[4,5]imidazo[2,1-b]quinazoline | CHEMBL341271
Type:
Small organic molecule
Emp. Form.:
C14H13N3
Mol. Mass.:
223.2731
SMILES:
C1CCc2nc3nc4ccccc4n3cc2C1
Structure:
Search PDB for entries with ligand similarity: