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Target
Endothelin-converting enzyme 1
Ligand
BDBM50084907
Substrate
n/a
Meas. Tech.
ChEMBL_225950 (CHEMBL843957)
IC50
1800±n/a nM
Citation
 De Lombaert, S; Blanchard, L; Stamford, LB; Tan, J; Wallace, EM; Satoh, Y; Fitt, J; Hoyer, D; Simonsbergen, D; Moliterni, J; Marcopoulos, N; Savage, P; Chou, M; Trapani, AJ; Jeng, AY Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J Med Chem 43:488-504 (2000) [PubMed]  Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1)
Type:
Enzyme
Mol. Mass.:
87155.11
Organism:
Homo sapiens (Human)
Description:
P42892
Residue:
770
Sequence:
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
  
Inhibitor
Name:
BDBM50084907
Synonyms:
3-Dibenzofuran-3-yl-2-(3-naphthalen-1-yl-1-phosphono-propylamino)-propionic acid | CHEMBL357251
Type:
Small organic molecule
Emp. Form.:
C28H26NO6P
Mol. Mass.:
503.4829
SMILES:
OC(=O)[C@H](Cc1ccc2c(c1)oc1ccccc21)NC(CCc1cccc2ccccc12)P(O)(O)=O
Structure:
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