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Target
Translocator protein
Ligand
BDBM50185957
Substrate
n/a
Meas. Tech.
ChEMBL_352427 (CHEMBL859958)
Ki
0.68±n/a nM
Citation
 Zhang, MR; Ogawa, M; Maeda, J; Ito, T; Noguchi, J; Kumata, K; Okauchi, T; Suhara, T; Suzuki, K [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. J Med Chem 49:2735-42 (2006) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50185957
Synonyms:
CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-2-phenoxyphenyl)acetamide | N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C24H24ClNO3
Mol. Mass.:
409.905
SMILES:
CC(C)Oc1ccccc1CN(C(C)=O)c1ccc(Cl)cc1Oc1ccccc1
Structure:
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