TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.0700nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.0740nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.0780nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.0980nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.190nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.540nMAssay Description:Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.680nMAssay Description:Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.820nMAssay Description:Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBRMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 0.830nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 4.80nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences
Curated by ChEMBL
National Institute Of Radiological Sciences
Curated by ChEMBL
Affinity DataKi: 18.1nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetMultidrug and toxin extrusion protein 1(Mus musculus)
Riken Center For Life Science Technologies
Curated by ChEMBL
Riken Center For Life Science Technologies
Curated by ChEMBL
Affinity DataKi: 145nMAssay Description:Inhibition of mouse Mate1 transfected in HEK293 cells assessed as uptake of [14C]-TEA preincubated for 15 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Mus musculus)
Riken Center For Life Science Technologies
Curated by ChEMBL
Riken Center For Life Science Technologies
Curated by ChEMBL
Affinity DataKi: 3.60E+3nMAssay Description:Inhibition of mouse Oct1 transfected in HEK293 cells assessed as uptake of [14C]-TEA preincubated for 15 mins by liquid scintillation counting analys...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 59.5nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 60.4nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 61.9nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 223nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 621nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of DNA topoisomerase 2 in human HeLa cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 887nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at rat TRPV1 expressed in human HEK293 cells assessed as inhibition of capsaicin-induced influx by measuring intracellular calciu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at rat TRPV1 expressed in human HEK293 cells assessed as inhibition of capsaicin-induced influx by measuring intracellular calciu...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of EGFR-TK in human MCF7 cells overexpressing EGFR incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of EGFR-TK in human HeLa cells overexpressing EGFR incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of EGFR-TK in human MCF7 cells overexpressing EGFR incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 3.66E+3nMAssay Description:Inhibition of EGFR-TK in human MCF7 cells overexpressing EGFR incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Antagonist activity at rat TRPV1 expressed in human HEK293 cells assessed as inhibition of capsaicin-induced influx by measuring intracellular calciu...More data for this Ligand-Target Pair
Affinity DataIC50: 4.05E+3nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at rat TRPV1 expressed in human HEK293 cells assessed as inhibition of capsaicin-induced influx by measuring intracellular calciu...More data for this Ligand-Target Pair
Affinity DataIC50: 4.33E+3nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 4.69E+3nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of DNA topoisomerase 2 in human HeLa cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Kyushu Institute Of Technology1-1 Sensuicho
Curated by ChEMBL
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of EGFR-TK in human HeLa cells overexpressing EGFR incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+4nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair