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Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50293811
Substrate
n/a
Meas. Tech.
ChEMBL_572238 (CHEMBL1031016)
IC50
>10000±n/a nM
Citation
 Nagase, T; Takahashi, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem 52:4111-4 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_HUMAN | ELOVL6 | FACE | LCE
Type:
PROTEIN
Mol. Mass.:
31392.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572238
Residue:
265
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE
  
Inhibitor
Name:
BDBM50293811
Synonyms:
3-endo-(Phenylsulfonyl)-N-[2-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide | CHEMBL549541
Type:
Small organic molecule
Emp. Form.:
C21H21F3N2O3S
Mol. Mass.:
438.463
SMILES:
FC(F)(F)c1ccccc1NC(=O)N1[C@@H]2CC[C@@H]1CC(C2)S(=O)(=O)c1ccccc1 |r,THB:21:19:13:15.16|
Structure:
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