Reaction Details Report a problem with these data
Target
Coagulation factor IX
Ligand
BDBM50307334
Substrate
n/a
Meas. Tech.
ChEMBL_610633 (CHEMBL1069647)
Ki
5900±n/a nM
Citation
 Wang, S; Beck, R; Blench, T; Burd, A; Buxton, S; Malic, M; Ayele, T; Shaikh, S; Chahwala, S; Chander, C; Holland, R; Merette, S; Zhao, L; Blackney, M; Watts, A Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem 53:1465-72 (2010) [PubMed]  Article 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM50307334
Synonyms:
5-(3,4-Dimethoxyphenyl)benzo[b]thiophene-2-carboxamidine | CHEMBL598384
Type:
Small organic molecule
Emp. Form.:
C17H16N2O2S
Mol. Mass.:
312.386
SMILES:
COc1ccc(cc1OC)-c1ccc2sc(cc2c1)C(N)=N
Structure:
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