Reaction Details
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Aurora kinase B
Ligand
BDBM50316482
Substrate
n/a
Meas. Tech.
ChEMBL_630516 (CHEMBL1104788)
IC50
8±n/a nM
Citation
Adams, ND; Adams, JL; Burgess, JL; Chaudhari, AM; Copeland, RA; Donatelli, CA; Drewry, DH; Fisher, KE; Hamajima, T; Hardwicke, MA; Huffman, WF; Koretke-Brown, KK; Lai, ZV; McDonald, OB; Nakamura, H; Newlander, KA; Oleykowski, CA; Parrish, CA; Patrick, DR; Plant, R; Sarpong, MA; Sasaki, K; Schmidt, SJ; Silva, DJ; Sutton, D; Tang, J; Thompson, CS; Tummino, PJ; Wang, JC; Xiang, H; Yang, J; Dhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem 53:3973-4001 (2010) [PubMed] Article More Info.:
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Inhibitor
Name:
BDBM50316482
Synonyms:
4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1Hpyrazol-4-yl]-N-[3-(4-methyl-1-piperazinyl)propyl]-1H-pyrrolo-[2,3-b]pyridine-2-carboxamide | CHEMBL1094705
Type:
Small organic molecule
Emp. Form.:
C34H39N9O2
Mol. Mass.:
605.7326
SMILES:
CCn1cc(c(n1)-c1ccc(NC(=O)Nc2ccccc2)cc1)-c1ccnc2[nH]c(cc12)C(=O)NCCCN1CCN(C)CC1
Structure:
