Reaction Details
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Aurora kinase C
Ligand
BDBM50241089
Substrate
n/a
Meas. Tech.
ChEMBL_630525 (CHEMBL1104797)
IC50
17±n/a nM
Citation
Adams, ND; Adams, JL; Burgess, JL; Chaudhari, AM; Copeland, RA; Donatelli, CA; Drewry, DH; Fisher, KE; Hamajima, T; Hardwicke, MA; Huffman, WF; Koretke-Brown, KK; Lai, ZV; McDonald, OB; Nakamura, H; Newlander, KA; Oleykowski, CA; Parrish, CA; Patrick, DR; Plant, R; Sarpong, MA; Sasaki, K; Schmidt, SJ; Silva, DJ; Sutton, D; Tang, J; Thompson, CS; Tummino, PJ; Wang, JC; Xiang, H; Yang, J; Dhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem 53:3973-4001 (2010) [PubMed] Article More Info.:
Target
Name:
Aurora kinase C
Synonyms:
Aurora/Ipl1-related kinase 3 | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora/Ipl1/Eg2 protein 2 | Serine/threonine-protein kinase 13 | AURKC_HUMAN | AURKC | AIE2 | AIK3 | AIRK3 | ARK3 | STK13 | Aurora-C/INCENP | Aurora Kinase C (Aurora-C) | Serine/threonine-protein kinase Aurora-C
Type:
Enzyme
Mol. Mass.:
35602.43
Organism:
Human
Description:
Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:
309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Inhibitor
Name:
BDBM50241089
Synonyms:
CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yloxy)propyl)amino)ethyl dihydrogen phosphate | 2-ethyl3-4-5-2-3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yloxy)propyl)amino)ethyl dihydrogen phosphate
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
